Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease

We did a deep dive into the immune response to SARS-CoV-2 vaccination in a young woman on immunosuppressive therapy. We showed that despite developing a T cell response, she did not develop neutralizing antibodies to protect against COVID-19 despite 3 doses of the vaccine.