Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

We looked into the action of the immune system in the blood of participants with and without Long COVID symptoms at 8 months after their COVID-19 infections. In those with Long COVID, we found differences in the activity of certain immune cells, suggesting that there may be a disruption in the communication between different parts of the immune system. This dysregulation may be contributing to inflammation and clinical symptoms associated with Long COVID. The researchers also found evidence that certain immune cells and proteins may be responding to lingering COVID-19 virus that remains in the body long after people recover from their acute infection.