Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms

Our laboratory scientists, working closely with our clinical scientists, measured the T cell (CD4 and CD8 cell) responses to COVID-19 over 8 months following infection. They were specifically looking at people with “long COVID” – symptoms that lasted at least 4 months following infection, in comparison to those who felt they had returned to normal.

Our scientists found subtle differences in the T cell responses in those who had “long COVID” compared to those who did not. Future work is exploring why this might be and what this finding means for those with persistent symptoms.