The Breadth of the Neutralizing Antibody Response to Original SARS-CoV-2 Infection is Linked to the Presence of Long COVID Symptoms

We investigated the continuing antibody response in LIINC participants months after their initial COVID-19 infection. We found that participants that had broader antibody responses 4 months following initial infection had greater odds of developing Long COVID and specifically experiencing gastrointestinal and neurological symptoms. Our findings suggest that relationships between various immune responses and Long COVID are likely complex but may involve the breadth of antibody neutralization responses.